2 miRs and Cancer January 13, 2007Posted by Sacha in Genetics, microRNA, News, Research, Science.
During all this kurfuffle of winter storms and sick kitties I failed to update you on an important microRNA breakthrough. At Ohio State University, Yuri Pekarsky’s team has found two microRNA (miRs) that regulate the most common human leukemia: B-cell chronic lymphocytic, or just B-CLL for short. These two microRNA are miR-29 and miR-181.
microRNA can function as reverse regulators of disease. So, when certain microRNA have low levels of expression, their targets genes are not surpressed and aggressive cancer can result. What the researchers found was that there was an inverse relationship between expression levels of miR-29 and miR-181 and Tcl1, the ocncogene associated with B-CLL.
The Ohio State team’s paper was titled “Tcl1 Expression in Chronic Lymphocytic Leukemia Is Regulated by miR-29 and miR-181″ and published in the December 15, 2006 edition of Cancer Research. According to the paper, “Because miR-29 and miR-181 are natural Tcl1 inhibitors, these miRs may be candidates for therapeutic agents in B-CLL-overexpressing Tcl1. ”